Protective Effects of Erythropoietin in Cardiac Ischemia
نویسندگان
چکیده
منابع مشابه
Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates hematopoiesis in the bone marrow. However, recent studies have also shown important nonhematopoietic effects of EPO. A functional EPO receptor is found in the cardiovascular system, including endothelial cells and cardiomyocytes. In animal studies, treatment with EPO during ischemia/reperfusion in the hear...
متن کاملProtective effect of erythropoietin in neonatal hypoxic ischemia in mice.
The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NFkappaB-immunoreactive neurons were o...
متن کاملcomparison of the protective effects of erythropoietin and melatonin on renal ischemia-reperfusion injury
conclusions treatment with epo and mel had a beneficial effect on renal ir injury. the results may also indicate that mel protects against morphological damage better than epo in renal ir injury. results ischemia-reperfusion significantly decreased the observed hb and hct values. the histopathological findings in the ir group confirmed that there was an increase in the hyaline cast and thickeni...
متن کاملProtective Effect of Erythropoietin in Renal Ischemia-Reperfusion Injury
Ischemia and/or reperfusion injury (IR) is one of the most common causes of acute renal failure. Erythropoietin (EPO), is main hematopoietic hormone that has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental I/R and toxicity models. Recent studies suggest that administration of exogenous EPO prevents ischemia-induced kidney damage. In this review w...
متن کاملThe potential protective effects of erythropoietin and estrogen on renal ischemia reperfusion injury in ovariectomized rats
Renal ischemia–reperfusion; Erythropoietin; Estrogen; Tumor necrosis factor-a; Myeloperoxidase activity; Nitric oxide Abstract Background: Renal ischemia–reperfusion (RIR) is an important etiopathological mechanism of acute renal failure (ARF). Erythropoietin (EPO) has been candidate as a nephroprotectant agent. However, its nephroprotective effect when it is accompanied with estrogen has not b...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2006
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2006.08.031